Derivation of a System-Independent Ki for P-glycoprotein Mediated Digoxin Transport from System-Dependent IC50 Data

Derivation of a system-independent Ki for Pgp-mediated digoxin transport from system-dependent IC50 data by accounting for the contribution of additional digoxin transporters

Derivation of a system-independent Ki for Pgp-mediated digoxin transport from systemdependentIC50 data

a study on construction of iranian life tables: the case study of modified brass logit system

چکیده ندارد.

Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine [seecomments].

BACKGROUND Although quinidine is known to elevate plasma digoxin concentrations, the mechanism underlying this interaction is not fully understood. Digoxin is not extensively metabolized, but it is known to be transported by the drug efflux pump P-glycoprotein, which is expressed in excretory tissues (kidney, liver, intestine) and at the blood-brain barrier. Accordingly, we tested the hypothesi...

Inhibition of P-Glycoprotein–Mediated Drug Transport A Unifying Mechanism to Explain the Interaction Between Digoxin and Quinidine

Background—Although quinidine is known to elevate plasma digoxin concentrations, the mechanism underlying this interaction is not fully understood. Digoxin is not extensively metabolized, but it is known to be transported by the drug efflux pump P-glycoprotein, which is expressed in excretory tissues (kidney, liver, intestine) and at the blood-brain barrier. Accordingly, we tested the hypothesi...